I've experimenting with different methods for lip-synching in my current project, Day of the Jackass, and the Pamela app really is fantastic. Problem is, AGS currently only supports .pam files for Sierra-style speech.
I understand why this is: character's mouths tend to be much smaller in non-Sierra-style games, so the effect would usually be lost. However, my project is hi-res, and the lip-synching would be quite noticable.
I've uploaded a little test I made to show how the game would look with Pamela support. I know it'd be a pain to implement this just for me, so I hope you like the result!