If you're making the game because you want to make it then who cares what other people think? Stop defending the game if it's for your amusement.
The girl isn't offensive, she just seems pointless. First you say that you drew her like that because:
"Hey, if we have to draw 20 frames of walking * 4 directions, plus pushing, pulling, talking, idleing, opening things etc animations all in whatever spare time we can muster, then it's going to be a girl. Nothing wrong with that. Honest."
Which, sure, is a funny joke. But then you say that there is a reason in the story why her breasts hang from her throat in huge melon shaped orbs.
So it's a story element... This leads me to believe that there is a part of the story where she puts on a nurses outfit that is 3 sizes too small and I really see how that can be a story element in a serious game so I'm inclined to believe that the game is a paradoy or humorous. Unless she is found in a tree and the only clothes they can find ever to clothe her is a nurses outfit 3 sizes too small and then all the other clothes in the world explode.
Ah, I see, I take it from some of your comments she's supposed to be a dream woman in all ways. A dream and an idealized dream woman. If that's your story then that's your story. If you don't want to give away any parts of the story and believe that the art is justified through story then stop defending it and just say "Wait and see!"
Also, I wouldn't say that you've recieved much venom. Squinky [oldschool] wrote she didn't like it in her blog and someone on the AG forums said they didn't want to play it based on the art. He was the most venomous and he was just one person.