This project looks really interesting and I'm looking forward to its completion.
Anyway, about your file size/GUI comments: The file size will have a great influence on how many people will download your finished game. Since you posted this thread here, I assume that you want people to download and play your game. IMHO, the file size is something you should care about. I'm not saying leave all those 3D scences. Just try to keep the size as small as possible. This way a lot more people will download and give you credit for your work. What's the use of a 100MB game that isn't played, because of the download size?
Concerning the new GUI, I prefer the old one, too. Not because it looks better, but because it is more functional. In your new GUI the verbs are in a single row on the bottom of the screen. This means that the player has to move the mouse quite a long way to access them all. The old GUI offers the verbs in three rows, so the mouse doesn't need to be moved so much. IMHO, the less time the player spends to access the GUI, the more time he/she has to enjoy the game. If you want people to enjoy your game, the design of the GUI is something you should care about, imo.
About the front standing view: She really looks like she is about to fall backwards. That's because she isn't standing in the right perspective...
Apart from that, your game looks very promising. I'm looking forward to this.