About the motel: Kind of. "The Event" that happened at The Sunshine Motel in 1961 caused room 10 to vanish from reality to the point were nobody even remembered that it had existed. That's the reason why the motel looks weirdly cut off at the end of the row there. Visiting the site with The Undeveloped Polaroid object and looking at it while walking around allows a person to view the room through it.
The objects are all items that, it is assumed, were in the room at the time of The Event and all have powers, from the useless ones to the insanely powerful ones.
Combining the objects completely changes what they do. I think it was combining the scissors with the alarm clock that produces the power to evaporate solid metal into gas.
There is a video of what happened during "The Conway Configuration" (or something like that), where several items were combined at the motel site, that is truly terrifying!