Well, another tester had the exact same problem so it's not an isolated incident. Couldn't get the game or winsetup to launch, but running in XP compatibility mode fixed it.
So, is this something related to Unawoved, or other games too?
Is it possible to narrow problem down by trying
a) games made with previous versions of AGS
b) other games made with AGS 3.4.1?
Additionally, you may ask testers to turn the log on by putting
in the acsetup.cfg.
The log will be found in C:\Users\YourUserName\Saved Games\.ags
Maybe it will contain some hint.
EDIT: There is another thing, winsetup actually initializes graphic drivers to be able to get list of supported resolutions. If this crash is related to one of them, that could explain why winsetup also does not run.
What about changing driver in acsetup.cfg by hand and trying if any of them works?
List of possible options is here:
https://github.com/adventuregamestudio/ags/blob/master/OPTIONS.md