I found this looking for an old Guess the Movie Title film, and have a few to add.
Firstly, I take it no one has mentioned Ghost in the Shell since it's so glaringly obvious, right? The films, the series, even the new prequel is quite unlike anything I've seen.
I recently picked up King of the Hill again too, good stuff. Brickleberry is tons of fun. (OHBOYOHBOYOHBOY!)
Classics include The Critic (achgem!) and Mission Hill.