As far as I know the High Sierra update broke a lot of Wineskin wrappers. The most common fix I have seen is to:
- Open wineskin settings
- Choose "set screen options"
- Uncheck "autodetect GPU"
- Choose "Done" to close screen options
- Under "Tools" tab, "Utilities" section, open winetricks
- Search for "videomemorysize"
- Select a videomemorysize option from the list that corresponds to the VRAM of your video card
- Choose "Run"
- Choose "Done"