There is one more setting we didn't try, as far I as I know 
If you go to "Advanced Settings" in the game setup, you can adjust the amount of memory used by AGS. At least in my version it defaults to 10MB, so if for some reason, your system is loading slow maybe you could set this to match the total of your loaded files. This should improve perfprmance, I suppose...

If you go to "Advanced Settings" in the game setup, you can adjust the amount of memory used by AGS. At least in my version it defaults to 10MB, so if for some reason, your system is loading slow maybe you could set this to match the total of your loaded files. This should improve perfprmance, I suppose...