What's the best software for sprites?

[Shane 'ProgZmax' Stevens]

Since I've championed Pro Motion's use as a pixel art toolkit from day one (and actively beta test it) I will add my vote for it being pretty much the PC IDEAL for mouse-based art.  If you use a tablet and prefer a more loose drawing style then photoshop is for you, though I will argue that it is crippled in the pixel art area because that is not what it was designed for.  Also, if you ever want any kind of full-featured studio for sprite production then photoshop is certainly the wrong choice, as is Paint.Net, regular paint and anything else that does not provide precision palettes, animation tools and support for tile-based grid work (traditional console rpg art).

[Half-Pint]

I prefer to use a program called Idraw3, also known as Chara maker, it was originaly made for Rpg maker i think but its pretty good for pixel art. I think you can download it for free if you can find it

[Ren]

Ill try Pro Motion. I see it's pretty popular.