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In every version of Maniac Mansion I've played, I was able to go into the kitchen early, and as soon as I see Nurse Edna, I run away from her and when I reach the door, she warps back to her room.  Is this going to be the same or similar?

Sounds fantastic.  This is gonna be big.  It's gonna be like on TV and stuff.  And I don't mean like that show with Joe Flaherty, bigger than that.

Really excited about this!  I'm so glad I stumbled upon this while looking for the phantom speech pack for deluxe.

May I suggest creating two modes for the game?  One that has all the death and mayhem of the original plus a warning if the game becomes unwinnable and one without death and unwinnability.  I like the low frustration of the later deathless failure-free LucasArts games too, but death in the original Maniac Mansion is just too hilarious to leave out of the game, plus you could do something with a "ghost" kid or have the dead kid's stuff be transferred to his/her next of kid (or still be usable).  Just a suggestion. This sounds like it will be special either way.

Here's a list of all the deaths possible at least with the NES version that I can remember:
Drown in the radioactive pool
Open the microwave after heating up a jar of radioactive water
Explode Weird Ed's hamster and return it to him
Get Sid/Razor a record contract and show it to Green Tentacle
Enter the Meteor's room without a radiation suit
Forget to turn the power on/refill the pool
Push the red button
Fail to get rid of the Meteor on time
Play a tape of the tentacle mating call to Green Tentacle (what does he do to you?!)